Open Mass Spectrometry Search Algorithm
Top Cited Papers
- 2 July 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 3 (5), 958-964
- https://doi.org/10.1021/pr0499491
Abstract
Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets. Keywords: protein identification • algorithm • bioinformatics • mass spectrometry • proteomics • significance testingThis publication has 20 references indexed in Scilit:
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