Urinary Excretion of Tamm-Horsfall Protein and Epidermal Growth Factor in Chronic Nephropathy
- 27 May 1998
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 79 (2), 167-172
- https://doi.org/10.1159/000045020
Abstract
Tamm-Horsfall protein (THP) and epidermal growth factor (EGF) are both synthesized by tubular cells in the distal part of the nephron and excreted with the urine. The present study examines the urinary excretion rates of the two peptides in relation to functional tubular markers in patients with chronic nephropathy. Four groups of patients with moderate to severely reduced renal function were studied: glomerulonephritis (n = 10), diabetic nephropathy (n = 11), tubulointerstitial nephropathy (n = 13), and polycystic kidney disease (n = 8). The renal function was evaluated by glomerular filtration rate (GFR) as an indicator for the general renal function, lithium clearance (CLi) as an indicator for proximal tubular function, and absolute distal reabsorption of sodium (ADRNa) as an indicator for distal tubular function. The excretion rate of EGF was rather closely correlated with GFR, CLi and ADRNa (Spearman coefficients of variation 0.88, 0.69, and 0.74, respectively). The correlations between the excretion rate of THP and GFR, CLi and ADRNa were weaker (Spearman coefficients of variation 0.68, 0.42, and 0.44). When the effect of GFR had been accounted for by multiple variance analyses, the excretion rates of the two peptides were still associated with ADRNa but not with CLi. In conclusion, the urinary excretion rates of especially EGF but also those of THP were correlated with renal function and distal tubular reabsorption of sodium in patients with chronic nephropathy.Keywords
This publication has 6 references indexed in Scilit:
- The Human Urinary Epidermal Growth Factor (EGF) PrecursorPublished by Elsevier BV ,1995
- Human epidermal growth factor—on molecular forms present in urine and bloodRegulatory Peptides, 1992
- Tubular secretion of Tamm-Horsfall protein in type 1 (insulin-dependent) diabetes mellitus using a simplified enzyme linked immunoassayClinica Chimica Acta; International Journal of Clinical Chemistry, 1992
- Excretion of epidermal growth factor (EGF) in diabetesClinica Chimica Acta; International Journal of Clinical Chemistry, 1990
- Epidermal Growth Factor And The KidneyAnnual Review of Physiology, 1989
- Human epidermal growth factor: renal production and absence from plasmaRegulatory Peptides, 1988