Synthesis of Monodisperse Biodegradable Microgels in Microfluidic Devices
- 22 September 2005
- journal article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 21 (23), 10275-10279
- https://doi.org/10.1021/la051527y
Abstract
Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mum sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins.Keywords
This publication has 21 references indexed in Scilit:
- Controlled Synthesis of Nonspherical Microparticles Using MicrofluidicsLangmuir, 2005
- MEMBRANE EMULSIFICATION AND MICROCHANNEL EMULSIFICATION PROCESSESReviews in Chemical Engineering, 2005
- Novel microreactors for functional polymer beadsChemical Engineering Journal, 2004
- Solvent‐Induced Self‐Assembly of a Meta‐Linked Conjugated Polyelectrolyte. Helix Formation, Guest Intercalation, and Amplified QuenchingAdvanced Materials, 2004
- Microfluidic Large-Scale IntegrationScience, 2002
- Droplet formation in a microchannel networkLab on a Chip, 2002
- Soft Lithography in Biology and BiochemistryAnnual Review of Biomedical Engineering, 2001
- Dynamic Pattern Formation in a Vesicle-Generating Microfluidic DevicePhysical Review Letters, 2001
- Biologically erodable microspheres as potential oral drug delivery systemsNature, 1997
- Dominant influence of atmospheric circulation on snow accumulation in Greenland over the past 18,000 yearsNature, 1995