Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes
- 3 March 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in The International Journal of Cell Cloning
- Vol. 28 (4), 713-720
- https://doi.org/10.1002/stem.402
Abstract
We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances tKeywords
Funding Information
- Institute for Cell Engineering and NIH (RC2 HL101582, NIH GM62437)
- Flight Attendant Medical Research Institute (FAMRI) Foundation
- Taiwan Merit Scholarship (NSC-095-SAF-I-564-019-TMS)
- japan society for promotion of science
This publication has 30 references indexed in Scilit:
- A chemical platform for improved induction of human iPSCsNature Methods, 2009
- Epigenetic reprogramming and induced pluripotencyDevelopment, 2009
- Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule CompoundsCell Stem Cell, 2008
- Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2Nature Biotechnology, 2008
- Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal FibroblastsThe International Journal of Cell Cloning, 2008
- Dissecting direct reprogramming through integrative genomic analysisNature, 2008
- Induced Pluripotent Stem Cell Lines Derived from Human Somatic CellsScience, 2007
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 2007
- Cellular and Physiological Effects of Short-Chain Fatty AcidsMini-Reviews in Medicinal Chemistry, 2004
- Krüppel-Like Factor 4 Is Transactivated by Butyrate in Colon Cancer CellsJournal of Nutrition, 2004