New insights into pancreatic cancer biology
Open Access
- 1 September 2012
- journal article
- research article
- Published by Elsevier BV in Annals of Oncology
- Vol. 23 (suppl_10), x135-x138
- https://doi.org/10.1093/annonc/mds313
Abstract
Pancreatic cancer remains a devastating disease. Over the last few years, there have been important advances in the molecular and biological understanding of pancreatic cancer. This included understanding of the genomic complexity of the disease, the role of pancreatic cancer stem cells, the relevance of the tumor microenvironment, and the unique metabolic adaptation of pancreas cancer cells to obtain nutrients under hypoxic environment. In this paper, we review the most salient developments in these few areas.Keywords
This publication has 34 references indexed in Scilit:
- Distant metastasis occurs late during the genetic evolution of pancreatic cancerNature, 2010
- The patterns and dynamics of genomic instability in metastatic pancreatic cancerNature, 2010
- Pancreatic CancerThe New England Journal of Medicine, 2010
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic AnalysesScience, 2008
- Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic CancerCell Stem Cell, 2007
- Tumor-stroma interactions in pancreatic ductal adenocarcinomaMolecular Cancer Therapeutics, 2007
- Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult MiceCancer Cell, 2007
- An In vivo Platform for Translational Drug Development in Pancreatic CancerClinical Cancer Research, 2006
- Cancer genes and the pathways they controlNature Medicine, 2004
- Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseCancer Cell, 2003