Body composition analysis using abdominal scans from routine clinical care in patients with Crohn’s Disease
- 7 February 2016
- journal article
- research article
- Published by Taylor & Francis Ltd in Scandinavian Journal of Gastroenterology
- Vol. 51 (7), 842-847
- https://doi.org/10.3109/00365521.2016.1161069
Abstract
Objective: Crohn’s Disease is associated with body composition changes, which have important treatment and prognostic implications. Measurement of body composition usually requires dedicated scanning or measurement, with retrospective analysis of existing datasets impossible. We sought to determine whether single slice analysis of abdominal scans, obtained during routine clinical care, in patients with Crohn’s Disease accurately predicts body composition compartments. Materials and methods: Abdominal CT images of patients with Crohn’s disease were analyzed and comparison was made with total body fat-free mass, total body fat mass, femoral neck t-score, and other parameters reported from DXA, the reference method. Results: Thirty-seven subjects were identified, 15 male and 22 female, with a mean age of 43.8 years. There was significant correlation (Pearson r = 0.923, p < 0.001) between skeletal muscle area from CT and total fat-free mass measured by DXA. Similarly, total body fat mass correlated strongly (r = 0.928, p < 0.0001) with subcutaneous fat area. In this cohort of ambulatory Crohn’s Disease patients, low muscle mass/sarcopenia was prevalent and predictive of lower bone mineral density. Conclusions: Fat mass, fat-free mass, and appendicular skeletal muscle index can be predicted by analysis of a single CT slice in patients with Crohn’s Disease. Similar to published data from healthy subjects, the L3 vertebral body level provided the most robust correlation with most parameters. This study represents the first published use of routinely obtained abdominal imaging to demonstrate this relationship – and to predict body composition components – in patients with inflammatory bowel disease.Keywords
This publication has 32 references indexed in Scilit:
- Assessing skeletal muscle mass: historical overview and state of the artJournal of Cachexia, Sarcopenia and Muscle, 2014
- Systematic review: body composition in adults with inflammatory bowel diseaseAlimentary Pharmacology & Therapeutics, 2013
- Assessment and management of low bone density in inflammatory bowel disease and performance of professional society guidelines1Inflammatory Bowel Diseases, 2011
- Nutrition in Inflammatory Bowel DiseaseJournal of Parenteral and Enteral Nutrition, 2011
- Comparison Between Handgrip Strength, Subjective Global Assessment, Anthropometry, and Biochemical Markers in Assessing Nutritional Status of Patients with Crohn’s Disease in Clinical RemissionDigestive Diseases and Sciences, 2009
- Nutrition in Crohn diseaseCurrent Opinion in Gastroenterology, 2003
- American Gastroenterological Association medical position statement: Guidelines on osteoporosis in gastrointestinal diseases, This document presents the official recommendations of the American Gastroenterological Association (AGA) Committee on Osteoporosis in Gastrointestinal Disease. It was approved by the Clinical Practice Committee on September 21, 2002, and by the AGA Governing Board on November 1, 2002.Gastroenterology, 2003
- AGA technical review on osteoporosis in gastrointestinal diseasesGastroenterology, 2003
- Body Composition by Dual-Energy X-Ray Absorptiometry in Patients with Crohn's DiseaseScandinavian Journal of Gastroenterology, 1998
- Determinants of total body and regional bone mineral density in normal postmenopausal women--a key role for fat massJournal of Clinical Endocrinology & Metabolism, 1992