Application of ZnO Nanoparticle/Ion Liquid Modified Carbon Paste Electrode for Determination of Isoproterenol in Pharmaceutical and Biological Samples

Abstract

The aim of this work was using ZnO nanoparticles and a synthesized ion liquid (1-Methyl-3-butylimidazolium bromide) for modification of carbon pate electrode. This modified electrode was applied to determination of isoproterenol (IP). Under optimum pH of 7.0, the oxidation of IP in the presence of ZnO nanoparticles and ion liquid occurred at a potential about 520 mV and oxidation current was more than unmodified electrode. Square wave voltammetry was used for determination of linear dynamic range of the method. The plot of oxidation current vs. concentration was linear in the range of 0.08 to 800.0 μmol L⁻¹ IP and detection limit was calculated to be 0.04 μmol L⁻¹ IP. The diffusion coefficient (D = 2.9 × 10⁻⁶ cm² s⁻¹), and electron transfer coefficient (α = 0.78) for IP were also determined using electrochemical approaches. This method was also examined for determination of IP in pharmaceutical and biological samples.