Innate immune evasion strategies of influenza viruses
- 1 January 2010
- journal article
- review article
- Published by Future Medicine Ltd in Future Microbiology
- Vol. 5 (1), 23-41
- https://doi.org/10.2217/fmb.09.108
Abstract
Influenza viruses are globally important human respiratory pathogens. These viruses cause seasonal epidemics and occasional worldwide pandemics, both of which can vary significantly in disease severity. The virulence of a particular influenza virus strain is partly determined by its success in circumventing the host immune response. This article briefly reviews the innate mechanisms that host cells have evolved to resist virus infection, and outlines the plethora of strategies that influenza viruses have developed in order to counteract such powerful defences. The molecular details of this virus–host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirals are discussed.Keywords
This publication has 142 references indexed in Scilit:
- Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with LysosomesCell Host & Microbe, 2009
- Emerging antiviral targets for influenza A virusTrends in Pharmacological Sciences, 2009
- Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymeraseThe EMBO Journal, 2009
- Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-ICell Host & Microbe, 2009
- The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1Immunity, 2009
- The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNAImmunity, 2009
- Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activityAntiviral Research, 2008
- Structural Mechanism of RNA Recognition by the RIG-I-like ReceptorsImmunity, 2008
- Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swineVaccine, 2007
- Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial PneumoniaCell Host & Microbe, 2007