Selenium and cancer: Effects of selenium and of the diet on the genesis of spontaneous mammary tumors in virgin inbred female C3H/St mice
- 31 December 1978
- journal article
- Published by Elsevier BV in Bioinorganic Chemistry
- Vol. 8 (5), 387-396
- https://doi.org/10.1016/s0006-3061(00)80273-2
Abstract
Inbred female C3H/St mice exhibit the normal incidence of spontaneous mammary adenocarcinoma of 80~100% if they are maintained on a standard commercial laboratory diet containing 0.15 ppm of selenium with meat and dried skimmed milk as major sources of protein. The tumor incidence drops to 42% if animals of the same strain are kept on a diet containing 0.45 ppm of selenium, with fishmeal as the main source of protein. The tumor incidence declines further to 25, 19 and 10% if the animals in addition receive 0.1, 0.5, and 1.0 ppm of selenium in the drinking water. Selenium supplementation at these levels has no noticable adverse effects on weight-gains and survival of the mice. Selenium supplemented groups of animals also remained tumor-free forKeywords
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