Involvement of the PTEN–AKT–FOXO3a Pathway in Neuronal Apoptosis in Developing Rat Brain after Hypoxia–Ischemia
Open Access
- 22 July 2009
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 29 (12), 1903-1913
- https://doi.org/10.1038/jcbfm.2009.102
Abstract
The proapoptotic function of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphatase has been linked to its capacity to antagonize the phosphatidylinositol-3-kinase–Akt signaling...Keywords
This publication has 31 references indexed in Scilit:
- Dynamic FoxO transcription factorsJournal of Cell Science, 2007
- Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's diseaseNeurochemistry International, 2007
- FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cellsCell Death & Differentiation, 2006
- Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancerExperimental Gerontology, 2006
- Bisperoxovanadium compounds are potent PTEN inhibitorsFEBS Letters, 2004
- PI3K/Akt and apoptosis: size mattersOncogene, 2003
- PTEN in Neural Precursor Cells: Regulation of Migration, Apoptosis, and ProliferationMolecular and Cellular Neuroscience, 2002
- Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein ComplexJournal of Biological Chemistry, 2001
- The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C TerminusJournal of Biological Chemistry, 2001
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997