Immunocyte Ca 2+ Influx System Mediated by LTRPC2
- 17 August 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5533), 1327-1330
- https://doi.org/10.1126/science.1062473
Abstract
We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca 2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5′-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca 2+ -permeable nonselective cation channel and enabled Ca 2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca 2+ influx by activating LTRPC2 in immunocytes.This publication has 26 references indexed in Scilit:
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