Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope
Open Access
- 20 June 2011
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 208 (7), 1501-1510
- https://doi.org/10.1084/jem.20110574
Abstract
Subimmunogenic vaccination with an agonist mimetope of insulin converts naive T cells into regulatory T cells and prevents type 1 diabetes in NOD mice.This publication has 55 references indexed in Scilit:
- T cell receptor recognition of self and foreign antigens in the induction of autoimmunitySeminars in Immunology, 2011
- Enhancement of antigen-specific Treg vaccination in vivoProceedings of the National Academy of Sciences of the United States of America, 2010
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivoThe Journal of Experimental Medicine, 2010
- Diabetogenic T cells recognize insulin bound to IAg7in an unexpected, weakly binding registerProceedings of the National Academy of Sciences of the United States of America, 2010
- Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapyJournal of Autoimmunity, 2009
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTORProceedings of the National Academy of Sciences of the United States of America, 2008
- Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppressionProceedings of the National Academy of Sciences of the United States of America, 2008
- Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?Current Opinion in Immunology, 2008
- Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD miceThe Journal of Experimental Medicine, 2007
- Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like diseaseThe Journal of Experimental Medicine, 2007