From Metabolism to Ecology: Cross-Feeding Interactions Shape the Balance between Polymicrobial Conflict and Mutualism
- 1 November 2012
- journal article
- research article
- Published by University of Chicago Press in The American Naturalist
- Vol. 180 (5), 566-576
- https://doi.org/10.1086/667887
Abstract
Polymicrobial interactions are widespread in nature and play a major role in maintaining human health and ecosystems. Whenever one organism uses metabolites produced by another organism as energy or nutrient sources, it is called cross-feeding. The ecological outcomes of cross-feeding interactions are poorly understood and potentially diverse: mutualism, competition, exploitation, or commensalism. A major reason for this uncertainty is the lack of theoretical approaches linking microbial metabolism to microbial ecology. To address this issue, we explore the dynamics of a one-way interspecific cross-feeding interaction in which food can be traded for a service (detoxification). Our results show that diverse ecological interactions (competition, mutualism, exploitation) can emerge from this simple cross-feeding interaction and can be predicted by the metabolic, demographic, and environmental parameters that govern the balance of the costs and benefits of association. In particular, our model predicts stronger mutualism for intermediate by-product toxicity because the resource-service exchange is constrained to the service being neither too vital (high toxicity impairs resource provision) nor dispensable (low toxicity reduces need for service). These results support the idea that bridging microbial ecology and metabolism is a critical step toward a better understanding of the factors governing the emergence and dynamics of polymicrobial interactions.This publication has 46 references indexed in Scilit:
- The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene LossmBio, 2012
- Social evolution in multispecies biofilmsProceedings of the National Academy of Sciences of the United States of America, 2011
- Molecular and regulatory properties of a public good shape the evolution of cooperationProceedings of the National Academy of Sciences of the United States of America, 2010
- Rapid evolution of stability and productivity at the origin of a microbial mutualismProceedings of the National Academy of Sciences of the United States of America, 2010
- Characterizing a model human gut microbiota composed of members of its two dominant bacterial phylaProceedings of the National Academy of Sciences of the United States of America, 2009
- Polymicrobial interactions stimulate resistance to host innate immunity through metabolite perceptionProceedings of the National Academy of Sciences of the United States of America, 2009
- A Novel Exclusion Mechanism for Carbon Resource Partitioning in Aggregatibacter actinomycetemcomitansJournal of Bacteriology, 2007
- Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gutProceedings of the National Academy of Sciences of the United States of America, 2007
- A humanized gnotobiotic mouse model of host–archaeal–bacterial mutualismProceedings of the National Academy of Sciences of the United States of America, 2006
- Host-Bacterial Mutualism in the Human IntestineScience, 2005