Maintenance of in Vivo Tolerance by Persistence of Antigen
- 21 August 1992
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 257 (5073), 1130-1134
- https://doi.org/10.1126/science.257.5073.1130
Abstract
T cells of the immune system respond only to foreign antigens because those cells with reactivity for self proteins are either deleted during their development or rendered non-responsive (anergic). The maintenance of the nonresponsive state was found to require the continual exposure of the anergic T cells to antigen. When anergic T cells were removed from the self antigen by adoptive transfer to a mouse strain lacking the antigen or by in vitro culture, nonresponsiveness was reversed and the anergic cells returned to normal functional status.Keywords
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