Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
Open Access
- 26 August 2016
- Vol. 21 (9), 1125
- https://doi.org/10.3390/molecules21091125
Abstract
Three new triterpenoid alkaloids, namely buxmicrophyllines P–R (1–3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1–3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM).This publication has 12 references indexed in Scilit:
- Chemical Constituents of Plants from the Genus BuxusChemistry & Biodiversity, 2015
- Bioactive steroidal alkaloids from Buxus macowanii Oliv.Steroids, 2015
- Triterpenoid alkaloid derivatives from Buxus rugulosaNatural Products and Bioprospecting, 2011
- A New Triterpenoid Alkaloid from Buxus sempervirensZeitschrift für Naturforschung B, 2011
- Triterpenoid Alkaloids from Buxus microphyllaChemistry & Biodiversity, 2010
- Cytotoxic Triterpenoid Alkaloids from Buxus microphyllaJournal of Natural Products, 2009
- Three Steroidal Alkaloids fromBuxus microphyllaJournal of Asian Natural Products Research, 1999
- New Steroidal Alkaloids from the Roots of Buxus sempervirensJournal of Natural Products, 1999
- Novel Triterpenoidal Alkaloids from the Roots of Buxus SempervirensNatural Product Letters, 1998
- 836. Buxus alkaloids. Part V. The constitution of cyclobuxoxazine, a new skeletal alkaloid containing a tetrahydro-oxazine ringJournal of the Chemical Society, 1965