Subacute Sclerosing Panencephalitis

Abstract

ALTHOUGH a viral etiology for subacute sclerosing panencephalitis (SSPE) was first postulated by Dawson¹in 1933, the isolation of measles-like viruses from brain cell cultures established from biopsies of SSPE patients has been a recent accomplishment.^2-4 The SSPE agents, either present in brain biopsies of patients or isolated from their brain tissue maintained in culture, have been found to be pathogenic for ferrets,^5,6with encephalitis becoming manifest after a prolonged incubation period. Because of the difficulties involved in handling ferrets and the excessive costs of their maintenance, a search became necessary for another experimental host—an animal at least as susceptible as the ferret to SSPE infection, but easier to handle and less costly to maintain. The present study shows that the hamster meets these criteria; intracerebral inoculation of hamsters with human brain culture cells carrying the SSPE agents, or with cell-free SSPE virus, produces encephalitis. Materials and