Staphylococcal peptidoglycans induce arthritis
Open Access
- 17 September 2001
- journal article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 3 (6), 375-380
- https://doi.org/10.1186/ar330
Abstract
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.Keywords
This publication has 29 references indexed in Scilit:
- Peptidoglycan and Lipoteichoic Acid fromStaphylococcus aureusInduce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood ModelInfection and Immunity, 2000
- Protective role of NK1.1+ cells in experimentalStaphylococcus aureusarthritisClinical and Experimental Immunology, 1999
- Arthritis and sepsis caused by Staphylococcus aureus: Can the tissue injury be reduced by modulating the host's immune system?Molecular Medicine Today, 1998
- Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1RaArthritis & Rheumatism, 1996
- Influence of cytostatic agents on the pulmonary defence of mice infected with Klebsiella pneumoniae and on the efficacy of treatment with ceftriaxoneJournal of Infection, 1994
- Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatmentClinical and Experimental Immunology, 1994
- Peptidoglycan and teichoic acid from Staphylococcus epidermidis stimulate human monocytes to release tumour necrosis factor-α, interleukin-1β and interleukin-6FEMS Immunology & Medical Microbiology, 1993
- Peptidoglycan and teichoic acid fromStaphylococcus epidermidisstimulate human monocytes to release tumour necrosis factor-α, interleukin-1β and interleukin-6FEMS Immunology & Medical Microbiology, 1993
- Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint.Proceedings of the National Academy of Sciences of the United States of America, 1986