Probing Copper2+ Binding to the Prion Protein Using Diamagnetic Nickel2+ and 1H NMR: The Unstructured N terminus Facilitates the Coordination of Six Copper2+ Ions at Physiological Concentrations
- 1 March 2005
- journal article
- Published by Elsevier BV in Journal of Molecular Biology
- Vol. 346 (5), 1393-1407
- https://doi.org/10.1016/j.jmb.2004.12.043
Abstract
No abstract availableKeywords
This publication has 61 references indexed in Scilit:
- Mapping the functional domain of the prion proteinEuropean Journal of Biochemistry, 2003
- Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and IronJournal of Biological Chemistry, 2002
- XAFS study of the high-affinity copper-binding site of human PrP 91–231 and its low-resolution structure in solution 1 1Edited by I. A. WilsonJournal of Molecular Biology, 2001
- Prion Disease: A Loss of Antioxidant Function?Biochemical and Biophysical Research Communications, 2000
- Differential Contribution of Superoxide Dismutase Activity by Prion Protein in VivoBiochemical and Biophysical Research Communications, 2000
- Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrPPublished by Elsevier BV ,2000
- The N-Terminal Tandem Repeat Region of Human Prion Protein Reduces Copper: Role of Tryptophan ResiduesBiochemical and Biophysical Research Communications, 2000
- Brain Copper Content and Cuproenzyme Activity Do Not Vary with Prion Protein Expression LevelPublished by Elsevier BV ,2000
- Prion Protein Selectively Binds Copper(II) IonsBiochemistry, 1998
- Coordinating properties of the amide bond. Stability and structure of metal ion complexes of peptides and related ligandsChemical Reviews, 1982