Paediatric testicular cancer: an updated review of incidence and conditional survival from the Surveillance, Epidemiology and End Results database
- 8 October 2009
- journal article
- review article
- Published by Wiley in BJU International
- Vol. 104 (9), 1280-1283
- https://doi.org/10.1111/j.1464-410x.2009.08524.x
Abstract
To determine, using the Surveillance, Epidemiology, and End Results (SEER) population-based database, the epidemiological variables and update the understanding of testicular tumours in children, as knowledge of their incidence and survival is predicated upon multi-institutional cooperation. Using the SEER database, we ascertained the incidence rate, 5-year survival by disease stage at diagnosis, and 5-year conditional survival after surviving for 1–3 years for cases recorded between 1973 and 2005. We stratified the incidence rate by race and histology to examine if these factors affect disease characteristics. We identified 195 cases of testicular tumours in children from birth to age 14 years, and 785 for children aged 15–18 years. Yolk sac tumour was the most common testicular tumour, and overall, Caucasian children were most at risk and four times more likely to be affected than African-American children. The incidence rate of testicular tumour overall has not increased significantly since 1973. Conditional survival is excellent for all testicular malignancies, with a 1-year conditional survival (chance of surviving 5-years after having survived the first year) of 99.6%. We present an updated analysis of the SEER database for the incidence and survival of testicular tumours, and revisit the issue of whether the incidence of testicular tumours in children is increasing. We also present to our knowledge, the first calculation of conditional survival in children for this malignancy. There has been no significant increase in the incidence of testicular tumours for children aged <14 years. By contrast, the postpubertal group aged 15–18 years showed a reversal in this trend.Keywords
This publication has 11 references indexed in Scilit:
- Incidence of testicular germ cell cancers in U.S. children: SEER program experience 1973 to 2000Urology, 2006
- Testicular Cancer Incidence in Eight Northern European Countries: Secular and Recent TrendsCancer Epidemiology, Biomarkers & Prevention, 2004
- PREPUBERTAL TESTIS TUMORS: ACTUAL PREVALENCE RATE OF HISTOLOGICAL TYPESJournal of Urology, 2004
- Juvenile Granulosa Cell Tumor of the Testis: Contemporary Clinical Management and Pathological DiagnosisJournal of Urology, 2004
- Increasing Incidence of Testicular Cancer Worldwide: A ReviewJournal of Urology, 2003
- Trends in the incidence of testicular germ cell tumors in the United StatesCancer, 2002
- Clinical Behavior and A Contemporary Management Algorithm for Prepubertal Testis Tumors: A Summary of the Prepubertal Testis Tumor RegistryJournal of Urology, 2002
- Incidence of Testicular Cancer in the United States: Has the Epidemic Begun to Abate?American Journal of Epidemiology, 1999
- Increase in Testicular Cancer Incidence in Six European Countries: a Birth Cohort PhenomenonJNCI Journal of the National Cancer Institute, 1996
- Is testicular cancer incidence in blacks increasing?American Journal of Public Health, 1989