Sunitinib, a Novel Therapy for Anthracycline- and Cisplatin-refractory Malignant Pheochromocytoma
Open Access
- 4 March 2009
- journal article
- case report
- Published by Oxford University Press (OUP) in Japanese Journal of Clinical Oncology
- Vol. 39 (5), 327-331
- https://doi.org/10.1093/jjco/hyp005
Abstract
We report a case of malignant pheochromocytoma recurred after debulking surgery. A 17-year-old male patient visited our hospital for right flank pain. He had not experienced palpitations, headache, sweating or weight loss. Level of urinary catecholamine and its metabolite increased above normal values and abdominal computed tomography showed a huge right adrenal mass. One month after debulking surgery, anterior mediastinal and multiple liver metastases were found. These tumors had no response to two conventional regimens of combination chemotherapy (cyclophosphamide, vincristine, dacarbazine and anthracycline; and etoposide and cisplatin). We treated the patient with sunitinib, a multiple tyrosine kinase inhibitor. The tumor showed very good metabolic response to the therapy. In patient with malignant pheochromocytoma, sunitinib might be one therapeutic strategy for malignant pheochromocytomas.Keywords
This publication has 13 references indexed in Scilit:
- The diagnosis and management of malignant phaeochromocytoma and paragangliomaEndocrine-Related Cancer, 2007
- We Should Desist Using RECIST, at Least in GISTJournal of Clinical Oncology, 2007
- Current Treatment of Malignant PheochromocytomaJournal of Clinical Endocrinology & Metabolism, 2007
- The role of imatinib mesylate (Glivec) for treatment of patients with malignant endocrine tumors positive for c-kit or PDGF-REndocrine-Related Cancer, 2006
- Phase II Study of Temozolomide and Thalidomide in Patients With Metastatic Neuroendocrine TumorsJournal of Clinical Oncology, 2006
- Malignant pheochromocytoma: current status and initiatives for future progressEndocrine-Related Cancer, 2004
- The Diagnosis and Medical Management of Advanced Neuroendocrine TumorsEndocrine Reviews, 2004
- VEGF in 105 pheochromocytomas: enhanced expression correlates with malignant outcomeAPMIS, 2003
- Angiogenesis and Vascular Architecture in PheochromocytomasThe American Journal of Pathology, 2002
- New Guidelines to Evaluate the Response to Treatment in Solid TumorsJNCI Journal of the National Cancer Institute, 2000