Open Access Series of Imaging Studies: Longitudinal MRI Data in Nondemented and Demented Older Adults
- 1 December 2010
- journal article
- Published by MIT Press in Journal of Cognitive Neuroscience
- Vol. 22 (12), 2677-2684
- https://doi.org/10.1162/jocn.2009.21407
Abstract
The Open Access Series of Imaging Studies is a series of neuroimaging data sets that are publicly available for study and analysis. The present MRI data set consists of a longitudinal collection of 150 subjects aged 60 to 96 years all acquired on the same scanner using identical sequences. Each subject was scanned on two or more visits, separated by at least 1 year for a total of 373 imaging sessions. Subjects were characterized using the Clinical Dementia Rating (CDR) as either nondemented or with very mild to mild Alzheimer's disease. Seventy-two of the subjects were characterized as nondemented throughout the study. Sixty-four of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans, including 51 individuals with CDR 0.5 similar level of impairment to individuals elsewhere considered to have “mild cognitive impairment.” Another 14 subjects were characterized as nondemented at the time of their initial visit (CDR 0) and were subsequ...This publication has 39 references indexed in Scilit:
- Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface areaNeurobiology of Aging, 2009
- Regional white matter volume differences in nondemented aging and Alzheimer's diseaseNeuroImage, 2009
- Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCINeurobiology of Aging, 2008
- The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive IndividualsCerebral Cortex, 2008
- Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's DiseaseJournal of Neuroscience, 2008
- Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older AdultsJournal of Cognitive Neuroscience, 2007
- Age effects on atrophy rates of entorhinal cortex and hippocampusNeurobiology of Aging, 2006
- Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and MemoryJournal of Neuroscience, 2005
- Thinning of the Cerebral Cortex in AgingCerebral Cortex, 2004
- MR‐based hippocampal volumetry in the diagnosis of Alzheimer's diseaseNeurology, 1992