Adding to the Burden: Gastrointestinal Symptoms and Syndromes in Multiple Sclerosis
Open Access
- 17 September 2013
- journal article
- research article
- Published by Hindawi Limited in Multiple Sclerosis International
- Vol. 2013, 1-9
- https://doi.org/10.1155/2013/319201
Abstract
Background. Multiple sclerosis (MS) patients often suffer from gastrointestinal (GI) symptoms. However, the full extent and prevalence of such symptoms are not clearly established. Thus, we sought to define the prevalence of GI symptoms and syndromes in those with MS.Methods. 218 MS patients completed self-reported demographic and clinical data questionnaires as well as several standardized surveys probing MS severity and GI health.Results. Nearly two thirds (65.6%) of patients endorsed at least one persistent GI symptom. Constipation (36.6%), dysphagia (21.1%), and fecal incontinence (15.1%) were common. Surprisingly, nearly 30% (28.4%) of the patients reported dyspeptic symptoms. Using validated diagnostic algorithms, patients met criteria for functional dysphagia (14.7%), functional dyspepsia (16.5%), functional constipation (31.7%), and IBS (19.3%), among others. Functional dysphagia, functional dyspepsia, and IBS were significantly more common in those with self-identified mood disorders.Conclusions. Constipation, fecal incontinence, and dysphagia are indeed frequent symptoms seen in MS patients. We also noted a ~30% prevalence of dyspepsia in this population. The mechanisms driving this association are not clear and require further study. However, due to this high prevalence, dyspeptic symptoms should be incorporated into the routine assessment of MS patients and, if found, may warrant collaborative referral with a GI specialist.Keywords
Funding Information
- Ethel Vincent Charitable Trust
This publication has 59 references indexed in Scilit:
- The Physical and Psychological Impact of Multiple Sclerosis Using the MSIS-29 via the Web Portal of the UK MS RegisterPLOS ONE, 2013
- Walking speed, rather than Expanded Disability Status Scale, relates to long-term patient-reported impact in progressive MSMultiple Sclerosis Journal, 2012
- Anorectal Dysfunction in Multiple Sclerosis: A Systematic ReviewISRN Neurology, 2012
- Adverse Events of Interferon Beta-1a: A Prospective Multi-Centre International ICH-GCP-Based CRO-Supported External Validation Study in Daily PracticePLOS ONE, 2011
- When to Initiate Disease-Modifying Drugs for Relapsing Remitting Multiple Sclerosis in Adults?Multiple Sclerosis International, 2011
- Neuromyelitis optica unique area postrema lesionsNeurology, 2011
- Impact of Functional Gastrointestinal Disorders on Survival in the CommunityThe American Journal of Gastroenterology, 2010
- Fecal Incontinence in US Adults: Epidemiology and Risk FactorsGastroenterology, 2009
- Approved and Investigational Uses of ModafinilDrugs, 2008
- Rating neurologic impairment in multiple sclerosisNeurology, 1983