Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
- 23 November 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 12 (1), 21-23
- https://doi.org/10.1038/nn.2230
Abstract
Activation of GABAA receptors can depolarize specific neuronal compartments, causing excitation. The authors report that hippocampal interneurons hyperpolarize pyramidal cells, irrespective of the location of their synapses, along the entire somato-dendritic axis. Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABAA receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.Keywords
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