Human [74Se]selenomethionine metabolism: a kinetic model
Open Access
- 1 November 1991
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 54 (5), 917-926
- https://doi.org/10.1093/ajcn/54.5.917
Abstract
A study was undertaken to investigate the pharmacokinetics of an organically bound form of selenium. Six adults received a single oral 200-μg dose of 74Se as L-selen-omethionine. A kinetic model was developed to simultaneously account for the appearance and disappearance of the tracer in plasma, urine, and feces. The model included absorption distributed along the gastrointestinal tract, uptake by the liver-pancreas subsystem, enterohepatic recirculation, distribution to two large tissue pools, and transport through four components of the plasma pool. Average turnover time of the plasma components varied from 0.01 to 1.1 d. The turnover time in the liver-pancreas subsystem ranged from 1.6 to 3.1 d. Turnover time ranged from 61 to 86 d in the peripheral tissues with the slowest turnover. The whole-body residence time was approximately five-fold greater than the turnover time of the tissue pool with the slowest turnover, reflecting substantial reutilization of labeled material.Keywords
This publication has 19 references indexed in Scilit:
- Kinetic Modeling of Selenium Metabolism in Nonpregnant EwesJournal of Nutrition, 1989
- Selenium and cancer.BMJ, 1988
- ASSOCIATION BETWEEN CARDIOVASCULAR DEATH AND MYOCARDIAL INFARCTION AND SERUM SELENIUM IN A MATCHED-PAIR LONGITUDINAL STUDYThe Lancet, 1982
- The metabolism of [75Se]selenomethionine in four womenBritish Journal of Nutrition, 1976
- The metabolism of [75Se]selenite in young womenBritish Journal of Nutrition, 1974
- Metabolic studies of [75Se]selenomethionine and [75Se]selenite in the ratBritish Journal of Nutrition, 1973
- Radio-isotope scanning in the diagnosis of pancreatic diseaseBritish Journal of Surgery, 1970
- 75Se-Selenomethionine in the Study of Protein and Amino Acid Metabolism of Adult RatsExperimental Biology and Medicine, 1970
- Selenium metabolismToxicology and Applied Pharmacology, 1966
- Se75-Selenomethionine for Visualization of the Pancreas by Isotope ScanningRadiology, 1962