Joint testing of genotype and ancestry association in admixed families
- 28 October 2010
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 34 (8), 783-791
- https://doi.org/10.1002/gepi.20520
Abstract
Current genome‐wide association studies (GWAS) often involve populations that have experienced recent genetic admixture. Genotype data generated from these studies can be used to test for association directly, as in a non‐admixed population. As an alternative, these data can be used to infer chromosomal ancestry, and thus allow for admixture mapping. We quantify the contribution of allele‐based and ancestry‐based association testing under a family‐design, and demonstrate that the two tests can provide non‐redundant information. We propose a joint testing procedure, which efficiently integrates the two sources information. The efficiencies of the allele, ancestry and combined tests are compared in the context of a GWAS. We discuss the impact of population history and provide guidelines for future design and analysis of GWAS in admixed populations. Genet. Epidemiol . 34:783‐791, 2010.Keywords
This publication has 28 references indexed in Scilit:
- Genetic Landscape of Eurasia and “Admixture” in UyghursAmerican Journal of Human Genetics, 2009
- Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in MexicoProceedings of the National Academy of Sciences of the United States of America, 2009
- Signals of recent positive selection in a worldwide sample of human populationsGenome Research, 2009
- Ancestry-related assortative mating in Latino populationsGenome Biology, 2009
- A Genome-wide Analysis of Admixture in Uyghurs and a High-Density Admixture Map for Disease-Gene DiscoveryAmerican Journal of Human Genetics, 2008
- Effect of genetic divergence in identifying ancestral origin using HAPAAGenome Research, 2008
- On the inference of ancestries in admixed populationsGenome Research, 2008
- A Genomewide Admixture Map for Latino PopulationsAmerican Journal of Human Genetics, 2007
- A Genomewide Single-Nucleotide–Polymorphism Panel with High Ancestry Information for African American Admixture MappingAmerican Journal of Human Genetics, 2006
- Reconstructing Genetic Ancestry Blocks in Admixed IndividualsAmerican Journal of Human Genetics, 2006