The Association Between Tumor Epidermal Growth Factor Receptor (EGFR) Mutation and Multiple Primary Malignancies in Patients With Adenocarcinoma of the Lungs
- 1 April 2015
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in American Journal of Clinical Oncology
- Vol. 38 (2), 147-151
- https://doi.org/10.1097/coc.0b013e318292f88c
Abstract
An increased incidence of multiple primary malignancies has been found in recent decades. However, the nature of the association between the epidermal growth factor receptor (EGFR) mutation status and multiple primary malignancies in patients with adenocarcinoma of the lungs is not clearly understood at this time. We retrospectively reviewed the data of our patients with adenocarcinoma of the lungs, and evaluated the association between the tumor EGFR mutation status and multiple primary malignancies. From December 2008 to November 2011, 655 pulmonary adenocarcinoma patients with tumor EGFR mutation data were available for analysis. Of them, 359 had EGFR mutations (including 336 classic EGFR mutations), 63 had double primary malignancies, and 7 had triple primary malignancies. Patients with classic EGFR mutations had a higher incidence of multiple primary malignancies than those without (P=0.042). Multiple primary malignancies occurred more frequently in patients with exon 19 mutations (including insertions, point mutations, or deletions) or exon 19 deletions than in patients without (P=0.037 and 0.032, respectively). Patients with any EGFR mutations or classic EGFR mutations survived longer than those who did not (P<0.001 and <0.001, respectively). Patients with multiple primary malignancies survived for a longer period than those without (P=0.006). Multiple primary malignancies occurred more frequently in patients with classic EGFR mutations, especially those with exon 19 deletions.Keywords
This publication has 24 references indexed in Scilit:
- Outcomes After Combined Modality Therapy forEGFR-Mutant and Wild-Type Locally Advanced NSCLCThe Oncologist, 2011
- Multiple primary cancer: an increasing health problem. Strategies for prevention in cancer survivorsEuropean Journal of Cancer Care, 2009
- The New Lung Cancer Staging SystemSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2009
- Lung Cancer as a Second Primary Malignancy: Increasing Prevalence and Its Influence on SurvivalAnnals of Surgical Oncology, 2009
- Primary lung cancer and extrapulmonary malignancyEuropean Journal of Cardio-Thoracic Surgery, 2007
- Prospective Phase II Study of Gefitinib for Chemotherapy-Naïve Patients With Advanced Non–Small-Cell Lung Cancer With Epidermal Growth Factor Receptor Gene MutationsJournal of Clinical Oncology, 2006
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib TherapyScience, 2004
- Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to GefitinibThe New England Journal of Medicine, 2004
- Diet and cancer: Evidence from associations of multiple primary cancers in the seer programCancer, 1988
- Multiple Primary Carcinomas of the Head, Neck, and LungThe Annals of Thoracic Surgery, 1982