In Vitro Activities of LTX-109, a Synthetic Antimicrobial Peptide, against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus
Open Access
- 1 August 2012
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 56 (8), 4478-4482
- https://doi.org/10.1128/aac.00194-12
Abstract
LTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and linezolid, by microdilution tests to determine MICs. Time-kill assays were performed against representative MRSA, vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) isolates. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus . This activity was not influenced by resistance to other antistaphylococcal agents.Keywords
This publication has 10 references indexed in Scilit:
- A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane DisruptionJournal of Medicinal Chemistry, 2011
- Multicenter Study To Determine Disk Diffusion and Broth Microdilution Criteria for Prediction of High- and Low-Level Mupirocin Resistance in Staphylococcus aureusJournal of Clinical Microbiology, 2010
- In Vitro Activity of Ceftaroline against Community-Associated Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Daptomycin-Nonsusceptible Staphylococcus aureus IsolatesAntimicrobial Agents and Chemotherapy, 2010
- Mupirocin Resistance among Methicillin-ResistantStaphylococcus aureus-Colonized Patients at Admission to a Tertiary Care Medical CenterJournal of Clinical Microbiology, 2009
- Trends in Antibacterial Use in US Academic Health CentersArchives of Internal Medicine, 2008
- Synthetic Antimicrobial Peptidomimetics with Therapeutic PotentialJournal of Medicinal Chemistry, 2008
- Antimicrobial Activities of Twenty Lysine-Peptoid Hybrids against Clinically Relevant Bacteria and FungiChemotherapy, 2008
- Outpatient antibiotic use in Europe and association with resistance: a cross-national database studyThe Lancet, 2005
- Outpatient antibiotic use in Europe and association with resistance: a cross-national database studyThe Lancet, 2005
- Method of reliable determination of minimal lethal antibiotic concentrationsAntimicrobial Agents and Chemotherapy, 1980