Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (6), 2325-2330
- https://doi.org/10.1128/aac.48.6.2325-2330.2004
Abstract
We report that the amiloride analogues 5-( N , N -hexamethylene)amiloride and 5-( N , N -dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.Keywords
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