Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Top Cited Papers
Open Access
- 8 May 2014
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
- Vol. 69 (Suppl 1), S4-S9
- https://doi.org/10.1093/gerona/glu057
Abstract
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown. The identification of pathways that control age-related inflammation across multiple systems is therefore important in order to understand whether treatments that modulate inflammaging may be beneficial in old people. The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging. This article reports the main outcomes of this session.Keywords
This publication has 41 references indexed in Scilit:
- Age-dependent alteration in muscle regeneration: the critical role of tissue nicheBiogerontology, 2013
- Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRHNature, 2013
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersNature, 2011
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotypeThe EMBO Journal, 2011
- Four faces of cellular senescenceThe Journal of cell biology, 2011
- Circulating mitochondrial DAMPs cause inflammatory responses to injuryNature, 2010
- IKK/NF‐κB and STAT3 pathways: central signalling hubs in inflammation‐mediated tumour promotion and metastasisEMBO Reports, 2009
- Immunosenescence: what does it mean to health outcomes in older adults?Current Opinion in Immunology, 2009
- The role of exercise and PGC1α in inflammation and chronic diseaseNature, 2008
- Motif module map reveals enforcement of aging by continual NF-κB activityGenes & Development, 2007