Morphogenesis and morphology of HIV structure-function relations
- 1 March 1989
- journal article
- review article
- Published by Springer Science and Business Media LLC in Archiv für die gesamte Virusforschung
- Vol. 106 (1-2), 1-13
- https://doi.org/10.1007/bf01311033
Abstract
Fine structure and antigenic make-up analysis of HIV were combined in a 2D model, from which functional aspects can be deduced. On the envelope 72 probably trimeric surface knobs (gp 120) are connected to the virion via the transmembrane protein gp41. Gp120 is shed during ageing of the virion, but host cell antigens stay firmly anchored to the envelope. Underneath the envelope, p17 forms the matrix protein layer, while the capsid of the double cone shaped core is built up of p24. The relation between biochemical findings and morphogensis and maturation of HIV as well as aspects of pathogenesis and vaccination are discussed.Keywords
This publication has 66 references indexed in Scilit:
- Recovery of antigenically reactive HIV‐2 coresJournal of Medical Virology, 1989
- Assembly of Animal Viruses at Cellular MembranesAnnual Review of Microbiology, 1988
- Ultrastructure of Human Immunodeficiency Virus Type 2Journal of General Virology, 1988
- Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptorCell, 1987
- The Morphology of Human Immunodeficiency Virus Particles by Negative Staining Electron MicroscopyJournal of General Virology, 1987
- Nonrandom association of cellular antigens with HTLV-III virionsHuman Immunology, 1987
- Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency VirusJournal of General Virology, 1986
- The effect of cerulenin on Moloney murine leukemia virus morphogenesisVirus Research, 1986
- Morphology and immunoelectron microscopy of AIDS virusArchiv für die gesamte Virusforschung, 1985
- Virus-like Particles in Bovine Sera for Tissue CultureJournal of General Virology, 1976