Ambulatory 24‐h oesophageal impedance–pH recordings: reliability of automatic analysis for gastro‐oesophageal reflux assessment
- 18 July 2006
- journal article
- research article
- Published by Wiley in Neurogastroenterology & Motility
- Vol. 18 (11), 978-986
- https://doi.org/10.1111/j.1365-2982.2006.00825.x
Abstract
Oesophageal pH-impedance monitoring allows detection of acid and non-acid gastro-oesophageal reflux (GOR) events. Visual analysis of impedance recording requires expertise. Our aim was to evaluate the efficacy of an automated analysis for GOR assessment. Seventy-three patients with suspected GORD underwent 24-h oesophageal pH-impedance monitoring. Recordings analysis was performed visually (V) and automatically using Autoscan function (AS) of Bioview software. A symptom index (SI) > or =50% was considered for a significant association between symptoms and reflux events. AS analysis detected more reflux events, especially non-acid, liquid, pure gas and proximal events. Detection of oesophageal acid exposure and acid reflux events was similar with both analyses. Agreement between V and AS analysis was good (Kendall's coefficient W > 0.750, P < 0.01) for all parameters. During pH-impedance studies, 65 patients reported symptoms. As compared to visual analysis, the sensitivity and specificity of a positive SI determined by AS were respectively 85.7% and 80% for all reflux events, 100% and 98% for acid reflux and 33% and 87.5% for non-acid reflux. Despite good agreement with visual analysis, automatic analysis overestimates the number of non-acid reflux events. Visual analysis remains the gold standard to detect an association between symptoms and non-acid reflux events.This publication has 15 references indexed in Scilit:
- Esophageal pH-Impedance Monitoring and Symptom Analysis in GERD: A Study in Patients off and on TherapyThe American Journal of Gastroenterology, 2006
- Addition of Esophageal Impedance Monitoring to pH Monitoring Increases the Yield of Symptom Association Analysis in Patients off PPI TherapyThe American Journal of Gastroenterology, 2006
- Determinants of perception of heartburn and regurgitationGut, 2006
- Normal values and day‐to‐day variability of 24‐h ambulatory oesophageal impedance‐pH monitoring in a Belgian–French cohort of healthy subjectsAlimentary Pharmacology & Therapeutics, 2005
- Symptom association analysis in ambulatory gastro-oesophageal reflux monitoringGut, 2005
- Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoringGut, 2005
- Aerophagia, gastric, and supragastric belching: a study using intraluminal electrical impedance monitoringGut, 2004
- Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas refluxGut, 2004
- The symptom-association probability: An improved method for symptom analysis of 24-hour esophageal pH dataGastroenterology, 1994
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986