AUTOIMMUNE (IDIOPATHIC) THROMBOCYTOPENIC PURPURA IN PREGNANCY AND THE NEWBORN
- 1 September 1977
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 84 (9), 679-683
- https://doi.org/10.1111/j.1471-0528.1977.tb12680.x
Abstract
The effects of autoimmune (or idiopathic) thrombocytopenic purpura (ATP) on 51 pregnancies in 29 women is presented. There is no convincing evidence that the clinical course of ATP is influenced by pregnancy. There was no increased incidence of obstetric complications. No problems were encountered following spontaneous vaginal delivery or low forceps delivery. There were no perinatal deaths. Twenty newborn infants were studied in detail and significant thrombocytopenia was present in half of them. The severity of thrombocytopenia in the newborn correlated closely with the severity of maternal disease; those women in clinical remission following splenectomy but with presumed high levels of antiplatelet antibodies were those most likely to be delivered of affected newborn infants. The cord blood platelet count was the most reliable guide to the potential severity of the neonatal thrombocytopenia. Platelet counts were lowest between the second and fourth days of neonatal life. The management of the severely affected infant is discussed.Keywords
This publication has 10 references indexed in Scilit:
- The management of the pregnant patient with idiopathic thrombocytopenic purpuraAmerican Journal of Obstetrics and Gynecology, 1976
- PLATELET ANTIBODY IN AUTOIMMUNE THROMBOCYTOPENIABritish Journal of Haematology, 1975
- Obstetric management of isoimmune thrombocytopeniaAmerican Journal of Obstetrics and Gynecology, 1974
- Qualitative Platelet Abnormalities in Idiopathic Thrombocytopenic PurpuraNew England Journal of Medicine, 1972
- Autoimmune thrombocytopenic purpura and the compensated thrombocytolytic stateAmerican Journal Of Medicine, 1971
- CHILD BEARING AND IDIOPATHIC THROMBOCYTOPENIC PURPURABJOG: An International Journal of Obstetrics and Gynaecology, 1966
- Congenital Thrombocytopenic Purpura Treated by Exchange TransfusionArchives of Disease in Childhood, 1961
- Idiopathic thrombocytopenic purpura and pregnancyAmerican Journal of Obstetrics and Gynecology, 1960
- On the Use of Exchange Transfusion in Neonatal Thrombocytopenic PurpuraActa Paediatrica, 1959
- PURPURA IN PREGNANCY WITH SPECIAL REFERENCE TO IDIOPATHIC THROMBOCYTOPENIC PURPURAThe Lancet, 1950