Epstein-Barr Virus (EBV)-associated Gastric Carcinoma
Open Access
- 29 November 2012
- Vol. 4 (12), 3420-3439
- https://doi.org/10.3390/v4123420
Abstract
The ubiquitous Epstein-Barr virus (EBV) is associated with several human tumors, which include lymphoid and epithelial malignancies. It is known that EBV persistently infects the memory B cell pool of healthy individuals by activating growth and survival signaling pathways that can contribute to B cell lymphomagenesis. Although the monoclonal proliferation of EBV-infected cells can be observed in epithelial tumors, such as nasopharyngeal carcinoma and EBV-associated gastric carcinoma, the precise role of EBV in the carcinogenic progress is not fully understood. This review features characteristics and current understanding of EBV-associated gastric carcinoma. EBV-associated gastric carcinoma comprises almost 10% of all gastric carcinoma cases and expresses restricted EBV latent genes (Latency I). Firstly, definition, epidemiology, and clinical features are discussed. Then, the route of infection and carcinogenic role of viral genes are presented. Of particular interest, the association with frequent genomic CpG methylation and role of miRNA for carcinogenesis are topically discussed. Finally, the possibility of therapies targeting EBV-associated gastric carcinoma is proposed.Keywords
This publication has 134 references indexed in Scilit:
- EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latencyThe EMBO Journal, 2012
- Viral MicroRNA Targetome of KSHV-Infected Primary Effusion Lymphoma Cell LinesCell Host & Microbe, 2011
- Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysisBritish Journal of Cancer, 2011
- The Epstein–Barr Virus BART microRNAs target the pro-apoptotic protein BimVirology, 2011
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- DNA Methyltransferase and Histone Deacetylase Inhibitors in the Treatment of Myelodysplastic SyndromesSeminars in Hematology, 2008
- The Epstein–Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cellsVirology, 2008
- Point mutations in EBV gH that abrogate or differentially affect B cell and epithelial cell fusionVirology, 2007
- Epstein-Barr virus (EBV)-encodedBARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expressionJournal of Medical Virology, 2005
- The history of cancer epigeneticsNature Reviews Cancer, 2004