Serum alpha‐fetoprotein and lens culinaris agglutinin‐reactive fraction of alpha‐fetoprotein in patients with hepatocellular carcinoma
- 1 August 1993
- journal article
- Published by Wiley in Liver International
- Vol. 13 (4), 177-182
- https://doi.org/10.1111/j.1600-0676.1993.tb00627.x
Abstract
A fraction of serum alpha-fetoprotein (AFP) reactive with lens culinaris agglutinin (LCA) was measured by affinity chromatography in serum samples from 102 patients with hepatocellular carcinoma (HCC) and 48 patients with chronic liver diseases without HCC. Its usefulness as a marker of HCC was evaluated. The mean +/- SD percentage of this fraction in total AFP was 3.10 +/- 3.17% in 48 patients with chronic liver diseases without HCC. When the cut-off level was set at 12.6% (mean + 3 SD), the sensitivity was 36.3%, the specificity was 100%, and the accuracy was 56.7% in the 102 patients with HCC. This lentil lectin-reactive AFP was positive in 7 of 25 patients (28%) who had single small liver cancer (phi < 20 mm), suggesting its clinical usefulness as a tumor marker. The lentil lectin-reactive AFP showed no correlation with the serum concentration of AFP or des-gamma-carboxy prothrombin (DCP). In patients with HCC showing an AFP level of 20 ng/ml or above, the lentil lectin-reactive fraction is a highly specific tumor marker. We consider it to be useful as an adjunct in the diagnosis of HCC.Keywords
This publication has 14 references indexed in Scilit:
- α-fetoprotein: Reevaluation in hepatologyHepatology, 1990
- Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditionsGastroenterology, 1990
- Non-surgical treatment of hepatocellular carcinoma.The Japanese Journal of Gastroenterological Surgery, 1990
- Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patientsCancer, 1989
- The general rules for the clinical and pathological study of primary liver cancerSurgery Today, 1989
- Histological diagnosis of hepatocellular carcinoma by a new technique of ultrasound-guided fine needle biopsy.Kanzo, 1988
- 4. Hepatocellular CancerTumor Biology, 1987
- Fucosylation of serum α-fetoprotein in patients with primary hepatocellular carcinomaBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1985
- Detection of Vitamin K Deficiency by Use of an Enzyme-Linked Immunosorbent Assay for Circulating Abnormal ProthrombinPediatric Research, 1985
- Microheterogeneity of Alpha‐fetoprotein in Patient Serum as Demonstrated by Lectin Affino‐electrophoresisScandinavian Journal of Immunology, 1981