A General Introduction to Glucocorticoid Biology
Top Cited Papers
Open Access
- 4 July 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 10, 1545
- https://doi.org/10.3389/fimmu.2019.01545
Abstract
Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor superfamily of transcription factors. Despite their success, GCs are hindered by the occurrence of side effects and glucocorticoid resistance (GCR). Increased knowledge on GC and GR biology together with a better understanding of the molecular mechanisms underlying the GC side effects and GCR are necessary for improved GC therapy development. We here provide a general overview on the current insights in GC biology with a focus on GC synthesis, regulation and physiology, role in inflammation inhibition, and on GR function and plasticity. Furthermore, novel and selective therapeutic strategies are proposed based on recently recognized distinct molecular mechanisms of the GR. We will explain the SEDIGRAM concept, which was launched based on our research results.Keywords
Funding Information
- Agentschap voor Innovatie door Wetenschap en Technologie
- Universiteit Gent
- Fonds Wetenschappelijk Onderzoek
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