Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups
Open Access
- 14 February 2014
- journal article
- Published by Springer Science and Business Media LLC in Acta Neuropathologica Communications
- Vol. 2 (1), 18
- https://doi.org/10.1186/2051-5960-2-18
Abstract
Gangliogliomas are low-grade glioneuronal tumors of the central nervous system and the commonest cause of chronic intractable epilepsy. Most gangliogliomas (>70%) arise in the temporal lobe, and infratentorial tumors account for less than 10%. Posterior fossa gangliogliomas can have the features of a classic supratentorial tumor or a pilocytic astrocytoma with focal gangliocytic differentiation, and this observation led to the hypothesis tested in this study - gangliogliomas of the posterior fossa and spinal cord consist of two morphologic types that can be distinguished by specific genetic alterations.Keywords
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