Physiological Responses and Evaluation of Effects of BMI, Smoking and Drinking in High Altitude Acclimatization: A Cohort Study in Chinese Han Young Males
Open Access
- 8 November 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (11), e79346
- https://doi.org/10.1371/journal.pone.0079346
Abstract
High altitude acclimatization is a series of physiological responses taking places when subjects go to altitude. Many factors could influence these processes, such as altitude, ascending speed and individual characteristics. In this study, based on a repeated measurement design of three sequential measurements at baseline, acute phase and chronic phase, we evaluated the effect of BMI, smoking and drinking on a number of physiological responses in high altitude acclimatization by using mixed model and partial least square path model on a sample of 755 Han Chinese young males. We found that subjects with higher BMI responses were reluctant to hypoxia. The effect of smoking was not significant at acute phase. But at chronic phase, red blood cell volume increased less while respiratory function increased more for smoking subjects compared with nonsmokers. For drinking subjects, red blood cell volume increased less than nondrinkers at both acute and chronic phases, while blood pressures increased more than nondrinkers at acute phase and respiratory function, red blood cell volume and oxygen saturation increased more than nondrinkers at chronic phase. The heavy and long-term effect of smoking, drinking and other factors in high altitude acclimatization needed to be further studied.Keywords
This publication has 35 references indexed in Scilit:
- Platelet Inhibition by Nitrite Is Dependent on Erythrocytes and DeoxygenationPLOS ONE, 2012
- A study on BMI among the Bhotia of Uttaranchal, IndiaAsian Pacific Journal of Tropical Disease, 2011
- Obesity in Tibetans Aged 30–70 Living at Different Altitudes under the North and South Faces of Mt. EverestInternational Journal of Environmental Research and Public Health, 2010
- Variation in human performance in the hypoxic mountain environmentExperimental Physiology, 2010
- Does cigarette smoking affect the diagnostic reliability of hemoglobin α2δ2 (HbA2)?Journal of Clinical Laboratory Analysis, 2008
- Tobacco Smoke Hemoglobin Adducts in Maternal and Fetal BloodPolycyclic Aromatic Compounds, 2000
- An example of using mixed models and proc mixed for longitudinal dataJournal of Biopharmaceutical Statistics, 1997
- Ventilatory Responses to Acute and Chronic HypoxiaPublished by American Geophysical Union (AGU) ,1996
- Alcohol Consumption and Blood PressureThe New England Journal of Medicine, 1977