Stroke and bleeding risk assessment in atrial fibrillation: when, how, and why?
Open Access
- 20 December 2012
- journal article
- review article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 34 (14), 1041-1049
- https://doi.org/10.1093/eurheartj/ehs435
Abstract
Decision making with regard to thromboprophylaxis should be based upon the absolute risks of stroke/thromboembolism and bleeding and the net clinical benefit for a given patient. As a consequence, a crucial part of atrial fibrillation (AF) management requires the appropriate use of thromboprophylaxis, and the assessment of stroke as well as bleeding risk can help inform management decisions by clinicians. The objective of this review article is to provide an overview of stroke and bleeding risk assessment in AF. There would be particular emphasis on when, how, and why to use these risk stratification schemes, with a specific focus on the CHADS2 [congestive heart failure, hypertension, age, diabetes, stroke (doubled)], CHA2DS2-VASc [congestive heart failure or left ventricular dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled)-vascular disease, age 65–74 and sex category (female)], and HAS-BLED [hypertension (i.e. uncontrolled blood pressure), abnormal renal/liver function, stroke, bleeding history or predisposition, labile INR (if on warfarin), elderly (e.g. age >65, frail condition), drugs (e.g. aspirin, NSAIDs)/alcohol concomitantly] risk scores.This publication has 100 references indexed in Scilit:
- Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney DiseaseThe New England Journal of Medicine, 2012
- ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012European Journal of Heart Failure, 2012
- Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient dataThe Lancet, 2012
- The ATRIA Risk Scheme to Predict Warfarin-Associated Hemorrhage: Not Ready for Clinical UseJournal of the American College of Cardiology, 2012
- Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested modelsStatistics in Medicine, 2011
- CHADS2 and CHA2DS2-VASc Scores in the Prediction of Clinical Outcomes in Patients With Atrial Fibrillation After Catheter AblationJournal of the American College of Cardiology, 2011
- A New Risk Scheme to Predict Warfarin-Associated Hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) StudyJournal of the American College of Cardiology, 2011
- Moving the Tipping PointCirculation: Cardiovascular Quality and Outcomes, 2011
- Impact of Proteinuria and Glomerular Filtration Rate on Risk of Thromboembolism in Atrial FibrillationCirculation, 2009
- Comparison of Risk Stratification Schemes to Predict Thromboembolism in People With Nonvalvular Atrial FibrillationJournal of the American College of Cardiology, 2008