Standard, and novel cytotoxic and molecular-targeted, therapies for HNSCC: an evidence-based review
- 1 May 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Oncology
- Vol. 19 (3), 216-221
- https://doi.org/10.1097/01.cco.0000264952.98166.99
Abstract
(1) Head and neck squamous cell carcinoma is the sixth most frequently occurring cancer worldwide.(2) Chemotherapy has shown some success as part of multimodal treatment schedules for locally advanced, nonmetastatic head and neck squamous cell carcinoma, and too a much lesser extent for metastatic head and neck squamous cell carcinoma.(3) A recent meta-analysis of 32 studies involving >10,000 patients concluded that chemotherapy added to radiotherapy produces a large survival advantage relative to radiotherapy alone.(4) Concurrent or alternate chemoradiotherapy, with a schedule based on cisplatin, has an established place in the management of locally advanced nonmetastatic head and neck squamous cell carcinoma.Keywords
This publication has 40 references indexed in Scilit:
- A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neckBMC Cancer, 2006
- New approaches to enhance chemotherapy in SCCHNAnnals of Oncology, 2005
- Induction Chemotherapy for Head and Neck Cancer: Will History Repeat Itself?Journal of the National Comprehensive Cancer Network, 2005
- Molecular mechanisms of head and neck cancerDrug Discovery Today: Disease Mechanisms, 2004
- Novel agents and incremental advances in the treatment of head and neck cancerSeminars in Oncology, 2004
- Systemic chemotherapy for squamous cell head and neck cancerExpert Opinion on Pharmacotherapy, 2003
- Novel therapeutics for head and neck cancerCurrent Opinion in Oncology, 2002
- Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual dataThe Lancet, 2000
- Treatment with cisplatin and fluorouracil alternating with radiation favourably affects prognosis of inoperable squamous cell carcinoma of the head and neck: Results of a multivariate analysis on 273 patientsAnnals Of Oncology, 1997
- Adjuvant chemotherapy in head and neck cancerBritish Journal of Cancer, 1990