Tolerance strategies for stem-cell-based therapies
- 14 May 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 453 (7193), 330-337
- https://doi.org/10.1038/nature07041
Abstract
There is much interest in using embryonic stem cells to regenerate tissues and organs. For this approach to succeed, these stem cells or their derivatives must engraft in patients over the long term. Unless a cell transplant is derived from the patient's own cells, however, the cells will be targeted for rejection by the immune system. Although standard methods for suppressing the immune system achieve some success, rejection of the transplant is inevitable. Emerging approaches to address this issue include 're-educating' the immune system to induce tolerance to foreign cells and reducing the immune targeting of the transplant by administering 'self stem cells' instead of foreign cells, but each of these approaches has associated challenges.Keywords
This publication has 85 references indexed in Scilit:
- In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like stateNature, 2007
- Generation of germline-competent induced pluripotent stem cellsNature, 2007
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- The Production and Directed Differentiation of Human Embryonic Stem CellsEndocrine Reviews, 2006
- Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settingsReproductive BioMedicine Online, 2006
- Characterization and culture of human embryonic stem cellsNature Biotechnology, 2005
- Human Embryonic Stem Cells Possess Immune‐Privileged PropertiesThe International Journal of Cell Cloning, 2004
- The immunogenicity of human embryonic stem-derived cellsTrends in Biotechnology, 2004
- Characterization of the expression of MHC proteins in human embryonic stem cellsProceedings of the National Academy of Sciences of the United States of America, 2002
- Minor H antigens: genes and peptidesEuropean Journal of Immunogenetics, 2001