Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults
- 14 August 2014
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 371 (7), 635-645
- https://doi.org/10.1056/nejmoa1315727
Abstract
As compared with a standard-dose vaccine, a high-dose, trivalent, inactivated influenza vaccine (IIV3-HD) improves antibody responses to influenza among adults 65 years of age or older. This study evaluated whether IIV3-HD also improves protection against laboratory-confirmed influenza illness.Keywords
This publication has 23 references indexed in Scilit:
- Seasonal influenza vaccine provision in 157 countries (2004–2009) and the potential influence of national public health policiesVaccine, 2011
- Efficacy and safety of a live attenuated influenza vaccine in adults 60 years of age and olderVaccine, 2009
- Randomized, Double‐Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High‐Dose and Standard‐Dose Influenza Vaccine in Adults 65 Years of Age and OlderThe Journal of Infectious Diseases, 2009
- Influenza-Associated Hospitalizations in the United StatesJAMA, 2004
- Mortality Associated With Influenza and Respiratory Syncytial Virus in the United StatesJAMA, 2003
- Clinical Efficacy and Safety of the Orally Inhaled Neuraminidase Inhibitor Zanamivir in the Treatment of Influenza: a Randomized, Double-blind, Placebo-controlled European StudyJournal of Infection, 2000
- The predictive value of influenza symptomatology in elderly peopleFamily Practice, 1998
- Improvement of Inactivated Influenza Virus VaccinesThe Journal of Infectious Diseases, 1997
- The Efficacy of Influenza Vaccine in Elderly PersonsAnnals of Internal Medicine, 1995
- The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trialJAMA, 1994