Time Trends in Primary HIV-1 Drug Resistance Among Recently Infected Persons
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Open Access
- 10 July 2002
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 288 (2), 181-188
- https://doi.org/10.1001/jama.288.2.181
Abstract
Primary HIV-1 (human immunodeficiency virus type 1) resistance to antiretroviral drugs has been reported.1-10 The proportion of recently infected individuals who acquire HIV-1 that is resistant to 2 or more classes of antiretroviral drugs is 2.7% (1/37) in San Francisco,4 2.9% (2/70) in Geneva,10 3.8% (3/80) in New York City,8 and 1.4% (2/141) in Los Angeles, San Diego, Boston, and Denver.9 The potential for epidemic spread of resistant HIV-1 is difficult to assess because surveillance is limited to small numbers of participants at each geographic location and short duration of observation. In this study, we monitored recently infected and drug-naive individuals in San Francisco from June 1996 through June 2001 to assess time trends in primary drug resistance in a community with widespread use of anti-HIV therapies and where virologic drug failure is common.11,12Keywords
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