Endocytosis-dependent desensitization and protein synthesis–dependent resensitization in retinal growth cone adaptation
Open Access
- 9 January 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 8 (2), 179-186
- https://doi.org/10.1038/nn1380
Abstract
It has been proposed that growth cones navigating through gradients adapt to baseline concentrations of guidance cues. This adaptation process is poorly understood. Using the collapse assay, we show that adaptation in Xenopus laevis retinal growth cones to the guidance cues Sema3A or netrin-1 involves two processes: a fast, ligand-specific desensitization that occurs within 2 min of exposure and is dependent on endocytosis, and a slower, ligand-specific resensitization, which occurs within 5 min and is dependent upon protein synthesis. These two phases of adaptation allow retinal axons to adjust their range of sensitivity to specific guidance cues.Keywords
This publication has 51 references indexed in Scilit:
- An Alternative Strategy for Adaptation in Bacterial BehaviorJournal of Bacteriology, 2004
- Retinal Axon Response to Ephrin-As Shows a Graded, Concentration-Dependent Transition from Growth Promotion to InhibitionNeuron, 2004
- Organization and translation of mRNA in sympathetic axonsJournal of Cell Science, 2003
- Reading of concentration gradients by axonal growth conesPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2000
- Isolated endosomes from quiescent rat liver contain the signal transduction machineryFEBS Letters, 1998
- G protein-coupled receptor adaptation mechanismsSeminars in Cell & Developmental Biology, 1998
- THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENTAnnual Review of Neuroscience, 1998
- THE TWO-COMPONENT SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS: A Molecular View of Signal Transduction by Receptors, Kinases, and Adaptation EnzymesAnnual Review of Cell and Developmental Biology, 1997
- Control of EGF Receptor Signaling by Clathrin-Mediated EndocytosisScience, 1996
- Dansyl cadaverine regulates ligand induced endocytosis of interleukin‐8 receptor in human polymorphonuclear neutrophilsFEBS Letters, 1996