Evaluation of Renal Handling of Uric Acid in Essential Hypertension: Hyperuricemia Related to Decreased Urate Secretion

Abstract

The tubular transport of urate was studied in 40 hypertensive patients and in 20 normal subjects by means of pyrazinamide and benzbromarone tests. There was a marked decrease in urate excretion per nephron in hyperuricemic patients with essential hypertension. Serum uric acid correlated inversely with fractional excretion of urate (r = -0.7450, p