How Does Multistep Tumorigenesis Really Proceed?
Open Access
- 1 January 2015
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 5 (1), 22-24
- https://doi.org/10.1158/2159-8290.cd-14-0788
Abstract
Summary: Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state. This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells. Cancer Discov; 5(1); 22–4. ©2015 AACR.Keywords
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