Pathological aspects of lipid peroxidation
Top Cited Papers
- 13 September 2010
- journal article
- review article
- Published by Informa UK Limited in Free Radical Research
- Vol. 44 (10), 1125-1171
- https://doi.org/10.3109/10715762.2010.498478
Abstract
International audienceLipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressedKeywords
This publication has 100 references indexed in Scilit:
- Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disordersExperimental Gerontology, 2009
- 4-Hydroxy-2-Nonenal Induces Mitochondrial Dysfunction and Aberrant Axonal Outgrowth in Adult Sensory Neurons that Mimics Features of Diabetic NeuropathyNeurotoxicity Research, 2009
- Induction of CCR2‐dependent macrophage accumulation by oxidized phospholipids in the air‐pouch model of inflammationArthritis & Rheumatism, 2009
- An update on products and mechanisms of lipid peroxidationMolecular Nutrition & Food Research, 2009
- Oxidized phospholipids: Biomarker for cardiovascular diseasesThe International Journal of Biochemistry & Cell Biology, 2008
- Reactive oxygen species signaling in vascular smooth muscle cellsCardiovascular Research, 2006
- Free radicals, metals and antioxidants in oxidative stress-induced cancerChemico-Biological Interactions, 2006
- Oxidative stress in Parkinson's diseaseAnnals of Neurology, 2003
- Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenalCell Biochemistry and Function, 1993
- 4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acidBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990