Cellular transformation and the ‘morphologic phenotype’ of transformed cells
- 1 August 1978
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 274 (5672), 645-650
- https://doi.org/10.1038/274645a0
Abstract
Expression of the product of the transforming gene (src) of RNA tumour viruses promotes growth and usually alters the adhesion, appearance and surface properties of cultured fibroblasts. The latter group of properties termed the 'morphologic phenotype' of transformed cells is largely due to diminished cell-to-substratum adhesion. The role of cyclic AMP, cell surface protein (CSP), and other factors in producing the 'morphologic phenotype' are discussed. The effects of src expression bear a striking resemblance to the action of peptide hormones such as insulin on appropriate target cells.Keywords
This publication has 66 references indexed in Scilit:
- High molecular weight MAPs are part of the mitotic spindleThe Journal of cell biology, 1978
- F20C, a new fluorescent membrane probe, moves more slowly in malignant and mitogen-transformed cell membranes than in normal cell membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1978
- Coordinate control of collagen synthesis and cell growth in chick embryo fibroblasts and the effect of viral transformation on collagen synthesisJournal of Cellular Physiology, 1977
- Dimeric character of fibronectin, a major cell surface-associated glycoproteinBiochemical and Biophysical Research Communications, 1977
- Phosphorylation of filamin and other proteins in cultured fibroblastsBiochemical and Biophysical Research Communications, 1977
- CYCLIC AMP MEDIATES THE CONCANAVALIN A AGGLUTINABILITY OF MOUSE FIBROBLASTSThe Journal of cell biology, 1974
- Cyclic AMP levels in temperature sensitive SV40 transformed cell linesJournal of Cellular Physiology, 1974
- CONCOMITANT EFFECTS OF INSULIN ON SURFACE MEMBRANE CONFORMATION AND POLYSOME PROFILES OF SERUM-STARVED BALB/C 3T3 FIBROBLASTSThe Journal of cell biology, 1974
- Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virusBiochemical and Biophysical Research Communications, 1973
- Cyclic AMP levels in fibroblasts: Relationship to growth rate and contact inhibition of growthBiochemical and Biophysical Research Communications, 1971