Armadillo/β-catenin signals in the nucleus – proof beyond a reasonable doubt?
- 1 March 2003
- journal article
- perspective
- Published by Springer Science and Business Media LLC in Nature
- Vol. 5 (3), 179-182
- https://doi.org/10.1038/ncb0303-179
Abstract
Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is β-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/β-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/β-catenin.Keywords
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