Fluoroquinolone Resistance Linked to GyrA, GyrB, and ParC Mutations inSalmonellaentericaTyphimurium Isolates in Humans
Open Access
- 1 November 2003
- journal article
- case report
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 9 (11), 1482-1483
- https://doi.org/10.3201/eid0911.030317
Abstract
We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, β-lactamase–producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.Keywords
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