QT Prolongation and delayed atrioventricular conduction caused by acute ingestion of trazodone
- 20 January 2008
- journal article
- case report
- Published by Taylor & Francis Ltd in Clinical Toxicology
- Vol. 46 (1), 71-73
- https://doi.org/10.1080/15563650701275322
Abstract
Trazodone possesses minimal anticholinergic properties and, therefore, is generally regarded as having less cardiotoxic potential than other antidepressants. This report describes a young woman who developed significant QT prolongation and delayed atrioventricular nodal conduction after acute trazodone overdose. The case adds to the existing literature because it has a number of strengths, namely that confounding drugs and alcohol were lacking, trazodone exposure was confirmed by drug assay, and early presentation to hospital gave a valuable opportunity to study the time-course of the cardiac effects. This case reminds us to consider the possibility of cardiotoxic effects after trazodone overdose, even in young patients with no established cardiovascular disease.Keywords
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